• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Diluting dosage device, in which there is a dilution-liquid cylinder (20), a sample cylinder (30), a press knob (2), and a blocking valve (21). When the knob is depressed, the blocking valve is closed and the pistons (16 and 15) in the cylinders move rearwards, whereat dilution liquid flows into the dilution-liquid duct (2), and a certain quantity of sample into the sample duct (23). When the press knob is returned, the blocking valve is opened and the pistons push the sucked sample and a certain quantity of the dilution liquid out through the tip (7).
    公开号:SU1466665A3
    申请号:SU853971972
    申请日:1985-11-01
    公开日:1989-03-15
    发明作者:Тервамяки Юкка；Йярвимяки Кари
    申请人:Лабсистемз Ой (Фирма)；
    IPC主号:
    专利说明:

    The invention relates to dosing devices, by means of which a sample can be taken from a liquid, the sample is mixed with a dilution liquid, such as a reagent, in exact proportion, and the mixture is metered into another vessel, such as a test tube or beaker.
    The purpose of the invention is to improve the performance of the device.
    Figures 1 to 3 show the device, a section, examples of execution with a monostable spring-loaded membrane; in FIG. 4 and 5 - the same, examples of execution with an elastic membrane
    The dosing device comprises a housing I, on which cylinder 2 for the diluent and cylinder 3 for the samples are fixed. A piston 4 is mounted in cylinder 2 for a diluent, dividing it into first 5 and second 6 chambers. In cylinder 3 for samples installed
    a piston 7 dividing the cylinder into the first 8 and second 9 chambers. In the second chamber 6, a first spring 10 is installed, in the second chamber 9 a spring 11. The device includes a valve block 12, in which the first 13 and second 1.4 channels are made, with the channel 13 connected via the side branch pipe 15 and the check valve 16 to the diluent channel 17 from vessel 18 for diluent. Channel 14 is connected to channel 19 for supplying the sample. Channels 13 and 14 are interconnected, respectively, through the third 20 and fourth 21 channels and the blocking valve, made in the form of a monostable membrane 22, which is a gate valve 23 and 24. The membrane 22 is equipped with a spring 25 or is elastic. The piston 4 is equipped with a rod 26, on. which is installed with the possibility of
    . (
    cl
    displacement relative to the stem is the adjustment stop 27, kinematically connected with the control lever 28. The adjustment stop is made in the form of a nut connected to the rod on the thread and installed without the possibility of rotation relative to the housing 1.
    The piston 1 is provided with a rod 29, on which an adjustment stop 30, kinematically connected with the control lever 28, is mounted for movement relative to the rod. The adjustment limiter is 30 c. the form of a nut connected to the stem through a thread and installed without the possibility of rotation relative to the housing 1. At the end of the stem 26, an adjusting handle .31 of the displacement of the rod 26 is installed, and at the end of the stem 29 - an adjusting handle 32 of the moving rod 29,
    Case 1 is complete with a handle 33,
    ten
    15
    diluent. When the adjustment knob 31 is removed, the calibration nut 35 can be turned, setting the front limit of the piston.
    The installation of the dose for the sample is carried out with an adjustable limiter of 30 °.
    In addition, each dosing part is connected to a mechanism installed in the handle 33, in which rods 26 and 29 rotate rows of digital rings 36 and 37 by means of claws 38 and 39 and wheels 40 and 41. Thus, the adjustment volume of the liquid each part can be displayed in windows 24 and 43 in digital form
    IU, 0.1
    for example, um.
    with precision I or
    20
    The control lever 28 is set in such a way that it moves in the handle 33 along the guide rail 44 parallel to the rods 26 and 29 Limiter 45 on the lever 28 and the limit of which is set button 34, pin 25 on the handle define
    diluent. When the adjustment knob 31 is removed, the calibration nut 35 can be turned, setting the front limit of the piston.
    The installation of the dose for the sample is carried out with an adjustable limiter of 30 °.
    In addition, each dosing part is connected to a mechanism installed in the handle 33, in which the rods 26 and 29 turn the rows of digital rings 36 and 37 by means of the pins 38 and 39 and the wheels 40 and 41. parts can be displayed in windows 24 and 43 in digital form

    with precision I or
    The control lever 28 is mounted in such a way that it moves in the handle 33 along the guide rail 44 parallel to the rods 26 and 29 Limiter 45 on the lever 28 and the restriction
    zanna with lever control. At the end of the rod 26, a calibration nut 35 o is installed. The device is provided with a number of digital rings 36 and 37 with keys 38 and 39 and wheels 40 and 41, windows 42 and 43, rail 44, limiters 45 and 46, partitions 47 and 48,
    Dosing device operates as follows.
    Pressing the button 34 moves the control lever 28 which, interacting with the nuts 27 and 30, moves the pistons 4 and 7 through the rods 26 and 29, and from the vessel 18 through the channel 17, the check valve 16 and the channel 13, the diluent is sucked into the chamber 5, and the sample fluid is sucked through channels 19 and 14 into chamber 8.
    When suction in channels 13 and 14, a vacuum is created so that the membrane 22 tightly closes the seats 23 and 24, which is also promoted by the spring 25 or the elastic properties of the membrane. This prevents the movement of fluids through the block valve during the suction stage.
    By turning the adjustment knob 3, the rod 26 is turned, and the nut 27 is respectively displaced along the rod 26 accordingly. Thus, the dose is adjusted.
    five
    0
    0 5
    0
    five
    SRI limit of movement of the lever 28,
    The forward limit of movement of the pistons 4 and 7 is determined by the baffles 47 and 48, which are made in the handle 33, while the calibration nut 35 and the adjusting handle 32, respectively, are in contact with these partitions
     When the lever 28 moves backward (FIG. 2), the nuts 27 and 30, mounted on the rods 26 and 29, are moved back to those. then, until the limiter 45 on the bridge 28 rests on the limiter 46; At the same time, the sample is sucked through the channel 19, and the diluent liquid, such as reagent, through the channel 17,
    The movement of the pistons 4 and 7 to the initial position (Fig. 3) occurs with the help of springs 10 and 11, which were compressed during the implementation of the suction movement. When it is possible to return the lever 28 to its original position, the piston 7 in the cylinder 3 pushes the fluid out of the channel 19 into the reservoir, for example a row of measuring cups, and at the same time as the piston 4 begins to move in the cylinder 2 to the initial position, creating an excessive the pressure closes the check valve 16 and opens the membrane 22 of the seat 23, after which the diluent fluid begins to flow from channel 13 into channel 14
    five
    and from it through channel 19 to the same reservoir with liquid-sample, completely mixing with it. At the same time, the diluent fluid washes channel 19 from the sample fluid. Flushing is improved if the amount of diluent liquid is chosen to be significantly more borim than the amount of sample fluid, for example in a ratio of 10: 1 or 100: 1.
    Before starting the dosing, the volumes for the liquid in the device (channels, valves, cylinders) must be filled with diluent liquid,. the device must be purged. This is carried out.
    by moving the lever 28 back and forth several times, the diluent liquid fills all the channels and displaces the air. The excess liquid flowing out of the channel 19 is preferably drained back into the vessel (not shown).
    Adjusting mechanisms and systems for indicating the volumes of liquid of the measuring and dosing parts may have a construction that corresponds to the design of the adjusting mechanisms of the known manually operated large-scale pipetting devices.
    It is preferable to design the valve block 12, in which the vacuum in the channels 1A and 13 during the suction stage acts on the same side of the valve membrane, as this prevents the valve from opening during the suction stage, even if significant pressure difference between these channels.
    In the devices shown in FIG. 4 and 5, the blocking valve between blocks with different liquids consists of an elastic membrane 22, which can be made, for example, of silicone rubber. When the piston 4 returns to its original position under the action of the spring 10 and 11, an overpressure is created in the channel 20. In connection with this, the membrane 22 is supplied and the diluent flows. to channel 21 „
    As a suction valve for a diluent fluid, for example, a ball valve, a thief (figo) or a flap valve (Fig. 4 and 5) can be used:
    1466665
    As shown in FIG. 5, the device may have a stand on which it stands when the device is not. used or when fluid is added to vessel 18,
    Blocks with liquid can be attached to the handle one above the other (Figures 1-4) jc6oKy from one another 10 (fig) or the other SPOSOC50M. As shown in FIG. 4, the vessel 18 can be separated from the device, in this case only the inlet flexible tube connects to the valve block 12, 15 or, as shown in 4mg. 5, the vessel 18 can be placed above the valve block 12. Device may contain more dosing units.
    25
    thirty
    35
    权利要求:
    Claims (7)
    [1]
    20 claims
    I, A dosing device comprising a housing on which cylinders for a diluent and samples are mounted, each with a piston dividing the cylinder cavity into two chambers and connected to the valve connected to the control mounted on the housing a block in which the first and second channels are connected, respectively, connected to the first chambers of the cylinders, the first channel being connected through the side branch pipe and the check valve to the diluent supply channel, the second channel is connected to the channel for supplying The first and second channels are interconnected, respectively, through the third and fourth channels and a blocking valve, made in the form of a monostable membrane, which is a gate valve on the third and fourth channels, which, in order to improve the performance of the mouth The second chambers, the diluent cylinders and the springs are installed between the pistons and the cylinder heads. ,
    [2]
    2. A device according to Claim 1, wherein the monostable membrane is an elastic membrane.
    [3]
    3. A device according to Claim 1, in which it is so that on the rods there are adjusting stops mounted on the rods with respect to the rods relative to the rods, kinematically connected with the control lever.
    40
    50
    55
    five
    0
    five
    0 claims
    I, A dosing device comprising a housing on which cylinders for a diluent and samples are mounted, each with a piston dividing the cylinder cavity into two chambers and connected to the valve connected to the control mounted on the housing a block in which the first and second channels are connected, respectively, connected to the first chambers of the cylinders, the first channel being connected through the side branch pipe and the check valve to the diluent supply channel, the second channel is connected to the channel for supplying The first and second channels are interconnected, respectively, through the third and fourth channels and a blocking valve, made in the form of a monostable membrane, which is a gate valve on the third and fourth channels, which, in order to improve the performance of the mouth The second chambers, the diluent cylinders and the springs are installed between the pistons and the cylinder heads. ,
    2. A device according to Claim 1, wherein the monostable membrane is an elastic membrane.
    3. A device according to Claim 1, in which it is so that on the rods there are adjusting stops mounted on the rods with respect to the rods relative to the rods, kinematically connected with the control lever.
    40
    50
    55
    [4]
    4, The device according to p. 3, characterized in that the adjusting stopper is made in the form of a nut connected to the gatok through the thread and installed without the possibility of rotation relative to the body
    [5]
    5. A device according to Po3, about tl and often because at the ends of the rods there are installed adjustable or limiting devices for the movement of the rods.
    1 33 2B JO 47 // J
    GAL / I .///.)
    4666658
    [6]
    6. A device according to Po1, which is connected with the fact that a vessel for expansion valve is fixed on the valve block, the cavity of which is connected to the inlet of the check valve,
    [7]
    7. The device according to Clause I., of which is that the casing is made with a handle on which a push button is mounted associated with the control lever.
    32
    / 4 // 7
    . If. I 7 / j
    // J, //
    /five
    2
    Phage.Z
    FIG.
    nineteen
    FI.5
    类似技术:
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    US4572229A|1986-02-25|Variable proportioner
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    US3865549A|1975-02-11|Auto-analytical apparatus and analytical methods
    US4004602A|1977-01-25|Self-metering dual proportioner
    同族专利:
    公开号 | 公开日
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
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    US3656351A|1970-06-25|1972-04-18|Bio Data Corp|Pipette|
    FI46688C|1971-06-23|1973-06-11|Suovaniemi|Pipette|
    US3955930A|1975-04-07|1976-05-11|Justin Joel Shapiro|Automatic dilutor having coupled diluent and reagent plungers|
    GB1558931A|1976-06-03|1980-01-09|Brand Fa Rudolf|Diluting and pipetting apparatus|
    DE2624899A1|1976-06-03|1977-12-08|Brand Fa Rudolf|One handed dilution and pipetting device - for reagent and sample, e.g. for clinical analysis|
    DE2649014A1|1976-10-28|1978-05-03|Brand Fa Rudolf|Liq. mixing appts. for preparing analysis samples - dilutes predetermined volumes of sample with reactant using piston and cylinder|
    JPS5720485Y2|1976-12-17|1982-05-01|
    JPS5722112Y2|1977-02-25|1982-05-13|
    IT1089495B|1977-11-23|1985-06-18|Istituto Sireterapico E Vaccin|DOSING AND DILUTION PUMP|
    FI57543C|1978-06-02|1980-09-10|Suovaniemi Finnpipette|VOLUMREGLERBAR PIPETT|
    FI57542C|1978-06-02|1980-09-10|Suovaniemi Finnpipette|VOLUMREGLERBAR PIPETT|
    US4257268A|1979-08-24|1981-03-24|Data Packaging Corporation|Pipetter|
    FR2473124B1|1980-01-04|1982-06-25|Marteau D Autry Eric|
    US4327595A|1980-07-07|1982-05-04|Hamilton Company|Method and apparatus for simultaneous dilution and dispensation|
    FI62470C|1981-06-17|1983-01-10|Labsystems Oy|pipette|
    SE451164B|1982-03-22|1987-09-07|Erik Ohlin|DEVICE AND SET FOR SERIAL DILUTION OF A SAMPLE LIQUID|
    FI64752C|1982-06-29|1984-01-10|Labsystems Oy|VOLUME REGULATOR PIPETT|
    GB2130656A|1982-11-23|1984-06-06|Nat Res Dev|Dilution devices|
    US4501163A|1983-08-30|1985-02-26|Macdermott Bruce R|Adjustable micro-dispensing liquid pipet|JPS63141630A|1986-12-04|1988-06-14|Mitsubishi Heavy Ind Ltd|Catalytic reactor for stack gas treatment|
    DE3818238C2|1988-05-28|1992-03-26|Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De|
    ES2035210T3|1988-10-21|1993-04-16|Eppendorf-Netheler-Hinz Gmbh|DEVICE TO OPERATE PIPETTES.|
    US5104813A|1989-04-13|1992-04-14|Biotrack, Inc.|Dilution and mixing cartridge|
    US5125278A|1990-10-18|1992-06-30|V-Tech, Inc.|Volumetric pipette|
    US5232664A|1991-09-18|1993-08-03|Ventana Medical Systems, Inc.|Liquid dispenser|
    US5214968A|1992-01-06|1993-06-01|Drummond Scientific Company|Pipet filling and discharge device|
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    US20040191128A1|1992-05-11|2004-09-30|Cytologix Corporation|Slide stainer with heating|
    US5947167A|1992-05-11|1999-09-07|Cytologix Corporation|Dispensing assembly with interchangeable cartridge pumps|
    US6180061B1|1992-05-11|2001-01-30|Cytologix Corporation|Moving platform slide stainer with heating elements|
    DE19734599C2|1997-08-09|2000-11-23|Hirschmann Laborgeraete Gmbh|Multi-channel piston pipette|
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    US7416704B2|2000-06-26|2008-08-26|Vistalab Technologies, Inc.|Handheld pipette|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FI844320A|FI844320A|1984-11-02|1984-11-02|UTSPAEDNINGSDOSERINGSANORDNING.|
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